Introduction

Enalapril is an ACE (Angiotensin-Converting-Enzyme) inhibitor used to treat high blood pressure and heart failure primarily. It lowers blood pressure by reducing the narrowing of blood vessels.

Common side effects

Low blood pressure, dizziness, nausea, dry cough

Precautions

• Report the symptoms of angioedema (e.g. swelling of the face, lips, tongue or difficulty in breathing)
• Inform your doctor/pharmacist if you suffer from significant low blood pressure (fainting and lightheadedness) or consistent coughing

Who cannot take

• People with history of hereditary, idiopathic or ACEI-related angioedema
• People who took sacubitril within 36 hours

Cautions with other medicine/food

• Alcohol
• ARB such as losartan, valsartan (anti-hypertensives)
• Potassium supplements and potassium-sparing diuretics
• Nonsteroidal Anti-inflammatory drugs, such as Ibuprofen
• Allopurinol (reduce uric acid)
• Azathioprine, everolimus (Immunosuppressant)
• Lithium (antimanic agent)
• Heparins such as enoxaparin, tinzaparin (anticoagulants)

Pregnancy and breastfeeding

Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

簡介

Enalapril是一隻血管張力素轉化酶抑制劑 (ACEI)，可用於控制高血壓及治療心臟衰竭。Enalapril通過減少血管收縮來達到降低血壓的效果。

常見副作用

低血壓，頭暈，噁心，乾咳

注意事項

• 如有血管水腫的症狀，例如臉部、嘴唇、舌頭腫起、呼吸困難，請告知你的醫生／藥劑師
• 如有嚴重低血壓或持續咳嗽的情況，請告知你的醫生／藥劑師

不可服用的人士

• 有遺傳性或特發性血管水腫病史的人
• 36小時內曾經服用sacubitril 的人

一同服用時需要注意的藥物／食物

• 酒精
• ARB ，如 losartan, valsartan （抗高血壓藥）
• 補鉀和保鉀利尿劑
• 非類固醇類消炎止痛藥，如布洛芬
• Allopurinol (降尿酸)
• Azathioprine, everolimus (降免疫力藥）
• Lithium (抗躁症藥)
• Heparins 如 enoxaparin, tinzaparin （抗凝血藥）

懷孕及哺乳

D：針對孕婦的控制實驗或觀察研究中，已證實此藥對胎兒有危險性。但在考量利弊得失下，此藥對於治療的利益可能大於潛在的危險性。